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How do bacteria "siege the city" in the body? Another bacterial strategy is deciphered

Release date: 2019-12-27 Views: 0

Source: Biological Exploration  

Human cells have a unique response pattern to bacteria "resident" in them: programmed cell death, also known as apoptosis, can respond to the stress conditions of infected cells, causing them to quickly " suicide". Because of this rapid self-destruction process of human cells, pathogens cannot reproduce. However, there are still many bacteria that can escape the so-called exhaustion of somatic cells.

Researchers at the University of Cologne in Germany have found that certain bacteria prevent apoptosis by inhibiting the activity of effector caspase, allowing them to camp in cells. The results were published in Nature Microbiology.

http://doi.org/10.1038/s41564-019-0620-5

Shigella is a pathogen that causes bacterial dysentery in humans and is prevalent in developing countries. Researchers have found in a mouse model that lipopolysaccharides on the surface of Shigella can bind to caspase and block its process, which is the engine that initiates apoptosis. At the same time, bacteria lacking intact lipopolysaccharide can cause apoptosis, which prevents it from multiplying in the cell, which is then successfully eliminated by the immune system and no longer causes disease.

This characteristic strategy of bacteria can prevent the rapid death of host cells and protect the bacterial territory. The cracking of this strategy has helped to alleviate the current stalemate pattern of bacterial cells. Research on this specific lipopolysaccharide is expected to resist and solve the bad consequences caused by bacterial infections in the future.

References:

[1] Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

[2] Bacteria can 'outsmart' programmed celldeath

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